Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells
نویسندگان
چکیده
منابع مشابه
Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells.
Cellular migrations through constricted spaces are a crucial aspect of many developmental and disease processes including hematopoiesis, inflammation and metastasis. A limiting factor in these events is nuclear deformation. Here, we establish an in vivo model in which nuclei can be visualized while moving through constrictions and use it to elucidate mechanisms for nuclear migration. C. elegans...
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Previous work has shown that C. elegans MEC-8 is a putative RNA-binding protein that promotes specific alternative splices of unc-52 transcripts. unc-52 encodes homologs of mammalian perlecan that are located extracellularly between muscle and hypodermis and are essential for muscle development in both embryos and larvae. We show that MEC-8 is a nuclear protein found in hypodermis at most stage...
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چکیده رساله/پایان نامه : تاکنون روشهای متعددی در ارتباط با مکان یابی خطا در شبکه انتقال ارائه شده است. استفاده مستقیم از این روشها در شبکه توزیع به دلایلی همچون وجود انشعابهای متعدد، غیر یکنواختی فیدرها (خطوط کابلی، خطوط هوایی، سطح مقطع متفاوت انشعاب ها و تنه اصلی فیدر)، نامتعادلی (عدم جابجا شدگی خطوط، بارهای تکفاز و سه فاز)، ثابت نبودن بار و اندازه گیری مقادیر ولتاژ و جریان فقط در ابتدای...
Microrheology of microtubule solutions and actin-microtubule composite networks.
We perform local or microrheological measurements on microtubule solutions, as well as composite networks. The viscoelastic properties of microtubules as reported from two-point microrheology agree with the macroscopic measurement at high frequencies, but appear to show a discrepancy at low frequencies, at time scales on the order of a second. A composite of filamentous actin (F-actin) and micr...
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Kinesin motor proteins carry out a range of transport functions in eukaryotic cells including long-distance transport in neurons and the movement of chromosomes during cell division. Because emerging microfluidic devices utilize channel geometries similar to cellular scales and because these devices generally require transport through these channels, there is significant interest in incorporati...
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ژورنال
عنوان ژورنال: Development
سال: 2016
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.141192